References

Transfer Factor Plus™ is supported by substantial published research, the following is a selected list of scientific and medical literature citations. Compiled by R. H. Bennett Ph.D., 4Life Medical Advisory Board

Immune Function

Pathogen interactions with cytokines and host defense: an overview. Seow HF Vet Immunol Immunopathol, 1998 May, 63:1?2, 139?48.

Mechanisms of viral clearance and persistence. Borrow PJ. Viral Hepat. 1997, 4 Suppl 2, 16?24.

Low?dose oral type I interferons reduce early virus replication of murine cytomegalovirus in vivo. Beilharz MW; McDonald W; Watson MW; Heng J; McGeachie J; Lawson CM. J Interferon Cytokine Res, 1997, 17:10, 625?30.

Carbohydrate recognition systems in innate immunity. Feizi T. Adv Exp Med Biol, 1998, 435, 51?4.

[Regulatory mechanisms of NK cell functions] Toyama Sorimachi N; Koyasu S Nippon Rinsho, 1999, 57:2, 304?9.

Human Natural Killer cells in health and disease. Biology and therapeutic potential. Whiteside TL; Herberman RB. Clin Immunother. 1994, 1:1, 56-66.

The role of Natural Killer cells in viral infections. See DM; Khemka P; Sahl L; Bui T; Tilles JG Scand J Immunol. 1997, 46:3, 217?24.

A role for NK cells in greater susceptibility of young rats to metastatic formation. Page GG; Ben Eliyahu S. Dev Comp Immunol. 1999, 23:1, 87?96.

Phenotypic Factors and Immune Function

Exercise and cellular innate immune function. Woods JA; Davis JM; Smith JA; Nieman DC. Med Sci Sports Exerc. 1999, 31:1, 57?66.

Aging and immune response to exercise. Shinkai S; Konishi M; Shephard RJ. Can J Physiol Pharmacol. 1998, 76:5, 562?7.

Natural Killer cells in healthy aging. Solana R; Alonso MC; Peta J. Exp Gerontol. 1999, 34:3, 435?43.

Immune dysfunction associated with chronic professional stress in nurses. De Gucht V; Fischler B; Demanet C. Psychiatry Res. 1999, 85:1, 105?11.

Suppression of Natural Killer cell activity in patients with fracture/soft tissue injury. Hauser CJ; Joshi P; Jones Q; Zhou X; Livingston DH; Lavery RF Arch Surg, 1997, 132:12, 1326?30

Evidence that stress and surgical interventions promote tumor development by suppressing Natural Killer cell activity. Ben Eliyahu S; Page GG; Yirmiya R; Shakhar G. Int J Cancer 1999, 80:6, 880?8.

Natural Killer Cell Lymphocytes

Regulation of adaptive immunity by Natural Killer cells. Kos FJ Immunol Res, 1998, 17:3, 303?12.

Role of Natural Killer cells in innate resistance to protozoan infections. Scharton Kersten TM; Sher A Curr Opin Immunol, 1997, 9:1, 44?51.

Impaired Natural Killer cell function as a consequence of aging. Albright JW; Albright JF Exp Gerontol, 1998, 33:1?2, 13?25.

Role of human Natural Killer cells in health and disease. Whiteside TL; Herberman RB. Clin Diagn Lab Immunol. 1994, 1:2, 125?33.

An In Vitro Screening Study of 196 Natural Products for Toxicity and Efficacy. See D, Gurnee K, LeClair M. J Am Nutraceutical Assoc. 1999, 2(1), 25-41.

Enhancement of Natural Killer (NK) cell Activity by Natural Products. See DM, Roshan R. Institute of Longevity Medicine. In press.

Colostral Transfer Factor

Process for obtaining transfer factor from colostrum transfer factor so obtained and use thereof. Wilson GB, Paddock GV. US Patent Number 4816563;Mar. 28, 1989.

Transfer Factor Biology

Breastfeeding Stimulates the Infant Immune System.. Hanson LA. Science and Medicine 1997, 2-11.

Review of the evidence for an association between infant feeding and childhood cancer. Davis MK. Int J Cancer Suppl, 1998, 11:, 29-33.

Peptide Sequences That Are Common to Transfer Factors. Kirkpatrick CH. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico

Transfer Factor Current status and future prospects. Lawrence HS, Borkowsky W. Biotherapy 1996, 9(1-3), 1-5.

A new basis for the immunoregulatory activities of transfer factor??an arcane dialect in the language of cells. Lawrence HS, Borkowsky W. Cell Immunol 1983, 82, 102?16.

Structural Nature and Functions of Transfer?Factors. Kirkpatrick CH. Annals of The New York Academy of Sciences 1993, 685, 362?368.

Peptide Sequences That Are Common to Transfer Factors. Kirkpatrick CH. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Transfer factor 1993: New frontiers. Fudenberg HH, Pizza G. Progress in Drug Res. 1994, 42, 309-400. Activities and characteristics of Transfer Factors. Kirkpatrick CH. Biotherapy 1996, 9(1-3), 13-6.

Effect of chain length on absorption of biologically active peptides from the gastrointestinal tract. Roberts PR, Burney JD, Black KW, Zaloga GP. Digestion 1999, 60, 332-7.

Murine Transfer Factors: dose-response relationships and routes of administration. Kirkpatrick C H, Hamad AR, Morton LC. Cell Immunol 1995, 164(2), 203-6.

Transfer Factor Therapy

Transfer factor in Malignancy. Pizza G., De Vinci C., Fudenberg HH. Progress in Drug Res. 1994, 42, 401-421.

Transfer Factor as a Good Therapeutic Agent in Moderate and Severe Atopic Dermatitis. Navarro-Cruz D, Serrano-Miranda E, Orea-S M, Estrada-Parra S, Teran-Ortiz L, Gomez-Vera J, Flores-Sandoval G. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Effect of in vitro produced transfer factor on the immune response of cancer patients. Pizza G, Visa D, Boucheix CI, Corrado F. Eur J Cancer 1977, 13, 917-23.

Treatment of Atopic Dermatitis with Transfer Factor and Cyclosporin A. Cordero-Miranda MA, Serrano-Miranda E, Flores-Sandoval G, Gomez-Vera J, Orea-S M, Correa-Meza B, Ramirez R, Badillo-Flores A, Estrada-Parra S. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Successful Treatment of Neuritis Posherpetca (Caused by Herpes Zoster) with Specific Transfer Factor. Ondarza R, Chavez R, Serrano E, Correa B, Ramirez R, Estrada-G I, Estrada-Parra S. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Epilepsy: Auxilary Treatment of Immunomodulators. Liu Baoquun, Xu Jiangyang, Wang Qin, Chen Guangliang. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Transfer Factor (Immodin Sevac) Treatment of Recurrent Anterior Uveitis A Retrospective Evaluation after Ten Years. Hana I, Stara J, Boguszakova J, Pekarek J, Ivaskova E. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Fifteen Years of Clinical Use of DLE-immodin in Czech Republic. Pekarek J, Cech K, Barnet K. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Twenty-five Years of Clinical Experience with Transfer Factor. Pizza G, De Vinci C, Palareti A, Viza D. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

The Transfer Factor in the Management of a Case of Encephalitis Caused by Coccidioides Immitis. Ayala-de la Cruz MC, Rodriguez-Padilla C, Tamez-Guerra R. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Suppurative Adenopathy by Salmonell B Treated with Transfer Factor. Case Report. Berron R, Almendarez C, Rosiles G. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Management of Hypereosinophilia with the Transfer Factor. Ayala-de la Cruz MC, Rodriguez-Padilla C. Tamez-Guerra R. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

The Use of Transfer Factor in a Case of Refractive Urinary Tract Infection. Ayala-de la Cruz MC, Rodriguez-Padilla C, Tamez-Guerra R. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Efficacy of the Transfer Factor in the Severely Infected Pediatric Patient. Ayala-de la Cruz MC, Rodriguez-Padilla C, Tamez-Guerra R. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Experience with Transfer Factor with 60 Patients in ICU. Sergio GG. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Cytokine and Lymphocyte Levels in Extrinsic Asthma Patients Treated with Transfer Factor. Enciso JA, Miranda ES, Gomez-Martinez JC, Portuguez-Diaz A, Badillo A, Orea-S M, Gomez-Vera J, Flores-Sandoval G, Estrada-Parra S. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

DLE Increase Stimulatory Effect of Cytokines on Hemopotesis. Barnet K, Vacek A, Cech K, Pekarek J, Schneiderova H. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Enhancing Effect of Transfer Factors on Granulocyte-macrophage Colony Forming Units of Immune-mediated Aplastic Anemia in vitro. Ferrer VE, Masso F, Montesinos JJ, Miranda E, Hernandez L, Ortiz B. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Biological and Clinical Testing of Swine Transfer Factor for Perorial Application (Imunor). Kral V, Richter J, Lastovicka J, Zehnulova M, Jilek D, Panajotovova L. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

TF, Psoriasis and Cytokines. Wang yuying, Liu Zhenxiang, Shen Li. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Observation of 26 Senile Cases Treated with P-TFOL. Wang Huifang, Zhou Guanghua, Yu Zhiying, Xu Yonggang, Jiang Jia Kun. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

Clinical Study of P-TFOL Liquid Treating Hepatitis. Wu Jing Xing, Jiang Jia Kun. XIth International Congress on Transfer Factor, 1-4 MAR 1999, Monterrey, Mexico.

In vitro studies during long-term oral administration of specific Transfer Factor. Pizza G, De Vinci C, Fornarola V, Palareti A, Baricordi O, Viza D. Biotherapy 1996, 9(1-3), 175-85. Oral bovine Transfer Factor (OTF) use in the hyper-IgE syndrome. Jones JF, et al. In: Immunobiology of Transfer Factor. Academic Press: New York. 1983, pp 261-70.

Thymic Factors

Thymocyte development in vitro: implications for studies of ageing and thymic involution. Montecino-Rodriguez E, Dorshkind K. Mech Ageing Dev. 1997, 93(1?3), 47?57.

Thymic involution in aging. Prospects for correction. Hadden JW, Malec PH, Coto J, Hadden EM. Ann NY Acad Sci. 1992, 673, 231?9. Thymus function, aging and autoimmunity. Rose NR. Immunol Lett. 1994, 40(3), 225?30.

The Thymus in Health and Senescence, Vol 1, Thymus and Immunity. Cardarelli N. CRC Press, Boca Raton, 1989. Gross murine leukemia virus?induced alterations in the thymus of preleukemic AKR mice. Beardsley TR; Hays EF. Cancer?Res. 1979, 39(2 Pt 1), 480?6.

Immunologic effects of human thymic stromal grafts and cell lines. Hays EF; Beardsley TR. Clin Immunol Immunopathol. 1984,33(3), 381?90.

Induction of T?cell maturation by a cloned line of thymic epithelium (TEPI). Beardsley TR; Pierschbacher M; Wetzel GD; Hays EF. Proc Natl Acad Sci USA. 1983, 80(19), 6005?9.

Immune-enhancing agent for therapeutic use in immunocompromised hosts. Beardsley TR. USP 5,616,554; 01 APR 1997. [Immunity of middle age and aged patients with tuberculosis and its changes during multimodality treatment by using T?activin] Adambekov DA; Litvinov VI; Mambetov KB; Koshmuratov AG; Sabyrbekova TS. Probl Tuberk, 1998, :5, 46?8

Activins and activin receptors in cell growth. Author Ying SY; Zhang Z; Furst B; Batres Y; Huang G; Li G. Proc Soc Exp Biol Med, 1997, 214:2, 114?22

[The lymphocyte subpopulation in patients with duodenal ulcer and the immunocorrective activity of thymalin and dalargin] Lukash NV; Polishchuk TF; Ludan VV. Lik Sprava, 1998, 3, 56?8

Research on the in vivo antitumoral action of thymosterin B in C57 black/6 mice implanted with melanoma B16 tumor. Potop I; Briese AM; Boeru V. Endocrinologie, 1984, 22:2, 97?101.

Influence of thymosterin on immunological reactivity in New Zealand mice. Rovensk J; Pekßrek J; Cebecauer L; Zitnan D; Svejcar J. Folia Biol (Praha), 1976, 22:4, 281?4.

The effect of experimental conditions on the assessment of T cell immunomodulation by biological response modifiers (thymosin fraction five). Talmadge JE, Benedict KL, Uithoven KA, Lenz BF. Immunopharmacology. 1984, 7(1), 17?26.

Immunomodulation and therapeutic characterization of thymosin fraction five. Talmadge JE, Uithoven KA, Lenz BF, Chirigos M. Cancer Immunol Immunother. 1984, 18(3), 185?94.

Immunomodulation of murine B16 melanoma metastasis: thymosin, thymectomy and irradiation. Naylor PH, Bhakoo HS, Paolini NS, Goldstein AL, Rosen F. Thymus. 1983, 5(5?6), 355?61.

Thymulin and its role in immunomodulation. Safieh?Garabedian B, Kendall MD, Khamashta MA, Hughes GR. J Autoimmun.1992, 5(5), 547?55.

Thymulin reduces hyperalgesia induced by peripheral endotoxin injection in rats and mice. Safieh?Garabedian B, Jalakhian RH, Saade NE, Haddad JJ, Jabbur SJ, Kanaan SA. Brain Res. 1996, 717(1?2), 179?83.

Regulatory T cells in thymic epithelium?induced tolerance. I. Suppression of mature peripheral non?tolerant T cells. Modigliani Y; Pereira P; Thomas Vaslin V; Salan J; Burlen Defranoux O; Coutinho A; Le Douarin N; Bandeira A. Eur J Immunol, 1995, 25:9, 2563?71.

Restoration of polymorphonuclear leukocyte function in elderly subjects by thymomodulin. Braga PC, Dal Sasso M, Maci S, Piatti G, Palmieri R, Bruno L, Albanese C. J Chemother. 1994, 6(5), 354?9

Zinc in Immune Function

The immunobiology of zinc. Wellinghausen N; Kirchner H; Rink L. Immunol Today 1997, 18(11):519-21.

Zinc and immune function: the biological basis of altered resistance to infection. Shankar AH; Prasad AS. Am J Clin Nutr 1998, 68:447S?463S.

The significance of zinc for leukocyte biology. Wellinghausen N; Rink L J Leukoc Biol, 1998, 64:5, 571?7.

Reversibility of the thymic involution and of age?related peripheral immune dysfunctions by zinc supplementation in old mice. Mocchegiani E, Santarelli L, Muzzioli M, Fabris N. Int J Immunopharmacol. 1995, 17(9), 703?18.

The effect of zinc and vitamin A supplementation on immune response in an older population. Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA. J Am Geriatr Soc 1998, 46:19?26.

Effect of zinc supplementation on the morbidity, immune function, and growth of low?birth?weight, full?term infants in northeast Brazil. Lira PI; Ashworth A; Morris SS. Am J Clin Nutr 1998, 68:418S?424S.

Interleukin 1 regulates secretion of zinc?thymulin by human thymic epithelial cells and its action on T?lymphocyte proliferation and nuclear protein kinase C. Coto JA; Hadden EM; Sauro M; Zorn N; Hadden JW Proc Natl Acad Sci USA. 1992, 89(16), 7752?6

Humoral and cell?mediated immunopotentiation in vaccinated chicken layers by thymic hormones and zinc. Barbour EK, Hamadeh SK, Ghanem DA, Haddad JJ, Safieh?Garabedian B. Vaccine. 1998, 16(17), 1650?5.

AIDS, zinc deficiency, and thymic hormone failure. Fabris?N; Mocchegiani?E; Galli?M; Irato?L; Lazzarin?A; Moroni?M. JAMA. 1988 Feb 12; 259(6): 839?40.

Role of zinc and alpha2 macroglobulin on thymic endocrine activity and on peripheral immune efficiency (Natural Killer activity and interleukin 2) in cervical carcinoma. Mocchegiani E; Ciavattini A; Santarelli L; Tibaldi A; Muzzioli M; Bonazzi P; Giacconi R; Fabris N; Garzetti GG. Br J Cancer 1999, 79:244?50.

Zinc?controlled Th1/Th2 switch significantly determines development of diseases. Sprietsma?JE. Med?Hypotheses. 1997 Jul; 49(1): 1?14.

Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue?specific protein. Antonia SJ; Geiger T; Miller J; Flavell RA. Int Immunol. 1995, 7:5, 715?25.

Plant Extracts and Immune Function

The mannose receptor mediates induction of IFN?alpha in peripheral blood dendritic cells by enveloped RNA and DNA viruses. Milone MC, Fitzgerald Bocarsly P. J Immunol, 1998, 161:5, 2391?9

The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. Zhu JS; Halpern GM; Jones K J Altern Complement Med, 1998, 4(3), 289?303.

The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. Zhu JS; Halpern GM; Jones K J Altern Complement Med, 1998, 4(4), 429-457.

Augmentation of various immune reactivities of tumor?bearing hosts with an extract of Cordyceps sinensis. Yamaguchi N; Yoshida J; Ren LJ; Chen H; Miyazawa Y; Fujii Y; Huang YX; Takamura S; Suzuki S; Koshimura S; et al Biotherapy, 1990, 2:3, 199?205.

Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism in the mouse. Manabe N; Sugimoto M; Azuma Y; Taketomo N; Yamashita A; Tsuboi H; Tsunoo A; Kinjo N; Nian Lai H; Miyamoto H Jpn J Pharmacol, 1996 Jan, 70:1, 85?8

[Influence of Cordyceps sinensis (Berk.) Sacc. and rat serum containing same medicine on IL?1, IFN and TNF produced by rat Kupffer cells] Liu P; Zhu J; Huang Y; Liu C Chung Kuo Chung Yao Tsa Chih, 1996, 21:6, 367?9, 384.

Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Chen YJ; Shiao MS; Lee SS; Wang SY Life Sci, 1997, 60(25), 2349?59.

[Effect of cordyceps sinensis on cellular immunity in rats with chronic renal insufficiency] Cheng Q Chung Hua I Hsueh Tsa Chih (Taipei), 1992, 72:1, 27?9, 63.

Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chen GZ; Chen GL; Sun T; Hsieh GC; Henshall JM Chin Med J (Engl), 1991, 104:1, 4?8.

Effects of cordyceps sinensis on Natural Killer activity and colony formation of B16 melanoma. Xu RH; Peng XE; Chen GZ; Chen GL Chin Med J (Engl), 1992, 105:2, 97?101.

[Effects of Cordyceps sinensis (CS) on in vitro Natural Killer cells] Liu C; Lu S; Ji MR Chung Kuo Chung Hsi I Chieh Ho Tsa Chih, 1992, 12:5, 267?9, 259.

[Effect of Jinshuibao capsule on the immunological function of 36 patients with advanced cancer] Zhou DH; Lin LZ Chung Kuo Chung Hsi I Chieh Ho Tsa Chih, 1995, 15:8, 476?8.

Cordyceps sinensis increases the expression of major histocompatibility complex class II antigens on human hepatoma cell line HA22T/VGH cells. Chiu JH; Ju CH; Wu LH; Lui WY; Wu CW; Shiao MS; Hong CY Am J Chin Med, 1998, 26(2), 159?70.

Antitumor activity of an extract of Cordyceps sinensis (Berk.) Sacc. against murine tumor cell lines. Yoshida J; Takamura S; Yamaguchi N; Ren LJ; Chen H; Koshimura S; Suzuki S Jpn J Exp Med, 1989, 59:4, 157?61.

[Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response] Zhu XY; Yu HY Chung Hsi I Chieh Ho Tsa Chih, 1990, 10:8, 485?7, 454.

The effects of Chinese herbs on improving survival and inhibiting anti?ds DNA antibody production in lupus mice. Chen JR; Yen JH; Lin CC; Tsai WJ; Liu WJ; Tsai JJ; Lin SF; Liu HW Am J Chin Med, 1993, 21:3?4, 257?62.

Cordyceps sinensis as an immunomodulatory agent. Kuo YC; Tsai WJ; Shiao MS; Chen CF; Lin CY Am J Chin Med, 1996, 24:2, 111?25.

[Short?term curative effect of cultured Cordyceps sinensis (Berk.) Sacc. Mycelia in chronic hepatitis B] Zhou L; Yang W; Xu Y; Zhu Q; Ma Z; Zhu T; Ge X; Gao J Chung Kuo Chung Yao Tsa Chih, 1990, 15:1, 53?5, 65.

[Experimental study on effect of Cordyceps sinensis in ameliorating aminoglycoside induced nephrotoxicity] Li LS; Zheng F; Liu ZH Chung Kuo Chung Hsi I Chieh Ho Tsa Chih, 1996 Dec, 16:12, 733?7

[Cordyceps sinensis in protection of the kidney from cyclosporine A nephrotoxicity] Zhao X; Li L Chung Hua I Hsueh Tsa Chih, 1993, 73:7, 410?2, 447.

Beta Glucan

Targeting of Natural Killer cells to mammary carcinoma via naturally occurring tumor cell?bound iC3b and beta?glucan?primed CR3 (CD11b/CD18). Vetvicka V; Thornton BP; Wieman TJ; Ross GD . J Immunol, 1997, 159:2, 599?605.

See ref 1-4. (1B>3)-?-D-Glucan as biological response modifiers: a review of structure-functional activity relationships. Bohn JA; BeMiller JN. Carbohydrate Polymers 1995, 28, 3-14.

Biological Response Modification by ?-D-Glucans. Goldman RC. Ann Reports Med Chem. 1995, 30, 129-138.

The effects of yeast polysaccharides on mouse tumors. Diller IC, Mankowski ZT, Fisher ME. Cancer Res. 1963, 23:201.

Therapeutic intervention with complement and beta?glucan in cancer. Ross GD; Vetvicka V; Yan J; Xia Y; Vetvickova J. Immunopharmacology. 1999, 42:1?3, 61?74.

Reduction of cell proliferation and enhancement of NK-cell activity. Shamsuddin AM. United States Patent 5,082,833; Jan 21, 1992.

Inositol hexaphosphate and inositol inhibit DMBA?induced rat mammary cancer. Vucenik I; Yang GY; Shamsuddin AM. Carcinogenesis, 1995, 16:5, 1055?8.

[3H]inositol hexaphosphate (phytic acid) is rapidly absorbed and metabolized by murine and human malignant cells in vitro. Vucenik I; Shamsuddin AM. J Nutr, 1994, 124:6, 861?8.

Up?regulation of the tumor suppressor gene p53 and WAF1 gene expression by IP6 in HT?29 human colon carcinoma cell line. Saied IT; Shamsuddin AM. Anticancer Res, 1998, 18:3A, 1479?84.

Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol?3' kinase. Huang C; Ma WY; Hecht SS; Dong Z. Cancer Res, 1997, 57:14, 2873?8.