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Letter from veterinarian :
Your product is great because it is mailed directly to the client for me.. I am very tired of being the warehouse for Merial and their products.

Enhanced Transfer Factor

The Veterinary Wellness Center

Applied Sciences and Quality of Patented Transfer Factor

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Here are some more details about TF+.

Perhaps more than you want to know.
Immunology is not a simple subject.
It is very, very complex.
It is one of those things that the more I know about it, the more I know I do not know.

Cytokines are protein molecules produced by cells of the immune system (such as T-cells and B-cells) for the communication of immune signals. Cytokines are mostly secreted in a soluble form, though some cytokines are known to exist attached on cell surface. Soluble cytokines secreted from one cell will bind specifically to their respective receptor molecules on the cell surfaces of the target cells.

The attachment of a Cytokine on its receptor will effect a specific immune signal within the target cell, such as to increase the production of antibodies against an invading virus or, often, to initiate the production of other cytokines so to pass on the signal. The term for this communication is "Signal Transduction".
Thus, through the secretion and exchange of various cytokines, the billions of cells in the immune system can function in a coordinated manner as well as responding efficiently against the invasion of foreign organisms. It is as if a mobilization of a great military armada. Or an organization of body defense and healing mechanisms to act in concert.

H.S. Lawrence discovered transfer factor in 1949, when he demonstrated that an immune fraction of a persons white blood cells was able to transfer immunity to a non sensitized individual.
Hence the name TRANSFER FACTOR.
It should be plural as there are a lot of them, not just one. As you note, that was 53 years ago. The clinical usefulness was severely limited by the costly and difficult preparation of Transfer Factors. They were prepared by dialyzing human WBC's.They were not much used in human medicine.

If you will forgive a digression, I never mention these facts without remembering that when I was first in a Veterinary Hospital. There was no Canine Distemper Vaccine.
Folk would bring their litters of hunting dog puppies to the hospital when they were 3-4 months old. We would board them for a week or so. It was my job to check and record their temperatures twice daily. At the second rise [Distemper produces a diphasic body temperature elevation] the pups would receive a small blood transfusion from our retired resident Bird Dog. They would recover from Distemper with the help of the Transfer Factors and of course produce their own active immunity at that point.
Thus I suppose it is fair to say that I have been using Transfer Factors in practice since 1947. Of course now they are available in a much more convenient form.

About 20 years ago, an immunologist was assigned to look into dry cow udder physiology and mastitis. He found large numbers of round cells there and eventually perceived that there were tremendous numbers of Transfer Factors in Bovine Colostrum. Some how this vital information lay unused until five or six years ago when some one realized its value.

The 4Life patent is on the process of extracting those Transfer Factors [there are lots of them not just one] from Bovine Colostrum and preserving their cellular integrity, sterility and capability. Transfer Factor[r] has been available for human use 4 years.

Only approved for Veterinary use last August. The remarkable fact is that the Transfer Factors are non species specific.
That is the cytokines for mine and your immune system are the same as for the Canine, Feline Equine; Most amazing to me. Of course that fact is what makes the Factors from Bovine Colostrum useful for humans.

Transfer factors are small molecules of 3,500-6,000 kDa [Daltons] molecular weight, consisting of oligoribonucleotides attached to a peptide molecule. In the past, they were derived from dialyzed white blood cells (WBC), but now can be purified from bovine Colostrum. [As stated above] They are produced by T-lymphocytes and can transfer the ability to recognize a pathogen to cells that have not been in contact with the pathogen (memory function).
They also heighten the immune system's ability to react (increased reactivity or inducer function) to pathogens. Transfer factor probably produces a trigger for T-cell recognition of antigen. On the other hand, it may act as a gene product that assists in antigen presentation to other T-cells.

(1) This INDUCER FRACTION of transfer factor; links the immune cells with an antigen-binding site, thereby increasing their reactivity to an antigenic stimulus.

(2) SPECIFIC ANTIGEN FRACTIONS "teach" the immune system to recognize, search out and destroy certain invading microorganisms. While the "memory" of these specific tasks is quite persistent, time does allow that "memory" to fade. A renewal of those "immune lessons" is required from time to time. This is the basis for administration of "Booster" Vaccines.

(3) NON SPECIFIC FRACTIONS instruct the immune system to recognize, and eliminate toxins and those cells that harbor toxins and the organisms that produce toxins.

(4) The SUPPRESSOR FRACTIONS block the response of the T-cells, and signals a down regulation of the immune response after an adequate response has been made. This is useful in allergic or autoimmune conditions. Never before has there been adequate treatment for autoimmune conditions such as Lupus, Auto Immune Hemolytic Anemia, Fibromyalgia and etc.

The immune system is amazingly complex. Without it we would quickly die from attack by micro organisms. Fortunately, nature gives us help from the neonatal stage by including Cytokines in Colostrum. We are realizing the importance of breast-feeding and immune competency. In this increasingly dangerous world, we are being assaulted by pathogen after pathogen.Many of which have become antibiotic resistant. Our immune systems are faltering.

Transfer factor (TF), the premier immune factor in colostrum, can be a vital part of our armamentarium. If one quantifies the capability of the immune system by the number of Natural Killer Cells [the large granulocyte lymphocytes] in an average blood sample; then the average patient's immune system today is about 20% LESS capable than it was 20 years ago. Transfer factor "trains" and continually "educates" the immune system.

Colostrum has a molecular weight 40,000 to 60,000 Daltons and as a result can not be absorbed by other than a neonate's digestive system. As you can see by some of our data whole Colostrum DOES increase immune system activity somewhat, so even after digestion some of the Factors are absorbed. However the Transfer Factors in our product have a molecular weight of 3,500 to 5,000 Daltons and are thereby readily absorbed intact.

It is said that in order to get from Colostrum the amount of Transfer Factors found in TF+, one would have to eat an impossible amount [dozens of pounds] and the cost would be $600 to $800 per dose.

To understand the usefulness of transfer factor, it is helpful to have an understanding of the TH1 helper/TH2 helper paradigm. T helper lymphocytes develop along two lines of cell populations. TH1 cells, which modulate cell-mediated immunity, produce the cytokines: IL-2, IFN-gamma, and TNF-alpha. TH2 cells, which modulate humoral immunity, or antibody production, produce IL-4, IL-5, IL-6, IL-10, and IL-13.
Once you are familiar with the particular TH1/TH2 predominant phenotypes in a patient, you can more easily identify certain constellations of diseases or conditions. Certain conditions can be expected and therapies can be designed accordingly.

Cell-mediated or TH1 helper responses are important in the body's ability to defend itself against viruses, fungi, parasites, cancer, and intracellular organisms. There are specific and non specific cytokines. That is one can isolate the biochemical messenger that instructs the immune system to defend against E. coli for instance and others that instruct the immune system to attack anything that is not autologous.

Our product should be named in plural for there are many Transfer Factors not just one Transfer Factor. Immunologically deficient cancer patients are susceptible to infection by viral pathogens, such as herpes zoster and cytomegalovirus (CMV). Infection occurs as a result of cytotoxic therapy, and deficiency of cell-mediated immunity. TH1-dominant states, characterized by increased amounts of IL-2 and IFN-gamma, are immuno-stimulatory and limit tumor growth. In contrast, TH2-predominant patterns, characterized by IL-4 and IL-10 cytokines, are immuno-inhibiting and stimulate tumor growth. HIV progression to HHV8 infection with Kaposi sarcoma, ulcerative colitis, progression to colon cancer, and obesity with increased incidence of carcinoma, are all associated with the increased TH2 state (and decreased cell-mediated immunity). Studies suggest that this shift to TH2 dominance precedes the cancerous transformation. As the cancer grows, it becomes increasingly hypoxic. This leads to further suppression of cell-mediated immunity, allowing decreased immune surveillance. Studies show that a TH2 immune response is associated with a proangiogenesis state, which facilitates cancer growth.

Transfer Factor is neither a vitamin, herb, mineral or supplement in the usual sense but a Nutraceutical and is licensed for distribution as a Nutraceutical.

The Oncology Department of the Teaching Hospital of the University of Georgia College of Veterinary Medicine is evaluating TF+ as an adjunct to protecting the immune system during chemotherapy and radiation therapy.

Mac Barksdale DVM

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These products are not intended to cure or treat disease. It is designed to enhance immune system function to optimal levels. The immune system enhancement is responsible for any clinical improvements.