I have had a problem which was never diagnosed by my medical doctors (it seems to be in the head) -culture negative and loads of antibiotics). My signs were consistent with interstitial cystitis. I experience unrelenting pain for days, and a very depressing life style for over 9 years. I started with enhanced transfer factors at 2 - 3 times daily and after about 10 - 14 days, went to maintenance dose, and whenever signs recurred a tingle - I took more. I only had 3 - 4 recurrences of signs which never developed, and this had never happened prior to taking enhanced transfer factors at any time. I have been 2 months sign-free, the longest I have ever been without signs. I am one of the successes of enhanced transfer factors . I am very pleased and grateful pleased to have quality of life back. Annie